Vitamin D deficiency is associated with an increased risk of cardiovascular death and progression of chronic kidney disease (CKD) in patients with early-stage disease.
Yanhong Lin, of Southern Medical University in Guangzhou, China, and colleagues examined the effects of 25-hydroxyvitamin D (25[OH]D) deficiency, known as calcifediol (a form of vitamin D produced in the liver), on cardiovascular mortality. And kidney outcomes in patients with early-stage chronic kidney disease.
The analysis included 9,229 adult patients with chronic kidney disease (stages 1 to 3) from 19 medical centers across China, from January 2000 to May 2021.
The researchers found that compared with patients with ≥20 ng/mL of calcifediol, there was a significantly higher risk of cardiovascular mortality and progression of chronic kidney disease, as well as a steeper annual decline in glomerular filtration rate (one of the measurements used to evaluate kidney function). , describes the estimated transudate flow rate in those with less than 10 ng/mL of calcifediol.
“25(OH)D deficiency was common in those with early-stage chronic kidney disease,” the researchers said. “Well-designed randomized clinical trials are needed to determine whether timely vitamin D supplementation can prevent cardiovascular events and loss of function.” Kidney disease in patients with early-stage chronic kidney disease and calcifediol deficiency.
The study was published May 11 in the Journal of Endocrinological Investigation.
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