Scientists explain the effect of excessive sleep during the holidays on health

It turns out to scientists that extra sleep on the weekend can reduce the risk of cardiovascular disease.

The Daily Mail reports that researchers from Nanjing Medical University, China, followed 3,400 people to determine how sleep cycles affect health.

According to the results of this study, people who did not regularly get enough sleep during weekdays and then slept a few extra hours on weekends had a 63 percent lower risk of heart attacks.

As for people who did not make up for lack of sleep on holidays, their risk of developing cardiovascular disease increased.

To prevent these diseases, doctors advise sleeping 7-8 hours a day.

It is noteworthy that previous studies have shown that an additional hour or two of sleep on weekends can prevent obesity and depression.

Common chemicals that may lead to the spread of cancer cells!

A new study found that when exposing colorectal cancer (CRC) cells to two different types of "forever chemicals" In the laboratory, this would likely accelerate cancer development.

The study analyzed exposure levels similar to those found in firefighters and other people who regularly handle perfluoroalkyl and polyfluoroalkyl substances (PFAS).

PFAS levels in firefighters' blood tend to be higher than levels in the general population, due to their frequent exposure to firefighting foam, which contains PFAS due to its flame-retardant properties.

In the new study, exposure to PFAS in the laboratory stimulated CRC cells to migrate to new sites, suggesting a possible role in the spread of cancer (metastasis) in living organisms.

“PFAS constitute a prevalent class of persistent organic pollutants that are of increasing public concern around the world,” says co-first author and physiologist Jie Cheng of Yale University. “They have been frequently detected in the environment, such as drinking water, indoor dust, cleaning products and paints.”

Many of these “eternal chemicals” remain They are found in everyday items, although the dangers of PFAS are largely unclear, partly due to the many different compounds found in them.

Research has shown that these long-lasting chemicals spread throughout the environment, and that exposure to high levels is associated with adverse health effects in humans and animals.

To study how it affects aggressive CRC, Cheng and his colleagues used CRC cells and lab-grown metabolomics, which measures levels of metabolites, thousands of small molecules such as amino acids, lipids and proteins.

Two types of CRC cells, shaped into balls called spheroids, were used in the experiments. The KRAS gene was present in one species, while the other species had a common mutation in the KRAS gene, which is associated with aggressive CRC.

When exposed to PFAS, the cells showed increased motility and a greater tendency to spread. In a different test of CRC cells grown in a flat layer, a line was scratched down the middle to divide them. When chemicals were introduced, the cells grew and moved toward each other again.

The researchers examined the effects of chemicals on cell metabolism. Exposure to PFAS altered various metabolites important for cell function, such as amino acids and fatty acids, as well as signaling proteins associated with metastasis.

The results suggest that exposure to high levels of PFAS could increase the risk of CRC spreading in real-life settings.

The team says this is important information for those who work in jobs where they are potentially exposed to high levels, and monitoring these chemicals is key to protecting their health, as is the case for future clinical studies.

The study was published in the journal Environmental Science and Technology.