Clinical Lipidology : "Small" food additives can lower high cholesterol levels!

A nutrition expert reveals how small dietary tweaks can be effective weapons in the fight against high cholesterol.

Alison Cullen, a nutritionist from A.Vogel, says that not eating enough protein and eating too many refined carbohydrates can limit the amount of cholesterol expelled from the body.

Based on research published in the Journal of Clinical Lipidology, Colleen recommended using avocado oil instead of solid fats and foods high in saturated fats, to control cholesterol in the body.

She recommends adding some polyphenol-rich berries to your diet, another research-backed adjustment to lower “bad” cholesterol levels.

The nutrition expert explained: “Eating 150 grams of berries daily for six weeks was associated with a statistically significant decrease in total cholesterol levels (6%), harmful cholesterol (7%), and triglycerides (27%).”

HDL cholesterol, also known as the “good” type, absorbs its harmful counterpart from the blood and carries it to the liver, where it is expelled from the body. Therefore, boosting “good” cholesterol levels can benefit overall cardiovascular health.

Colleen also advises the need to add foods rich in fiber, such as fruits, vegetables, nuts, and whole grains, which can help maintain cholesterol levels in the blood.

She also recommends eating oats as they are rich in soluble fiber, which can help lower cholesterol levels easily.

The expert added: "It appears that high-viscosity fibers such as those found in oats or barley have a greater impact on our health than wheat and rice fibers."

Coleen also advised combining dietary modifications with exercise, so that significant changes can be seen within two months.

 

Massachusetts Amherst : A new drug reverses obesity and lowers cholesterol in mice despite a high-fat diet!

A team of scientists has successfully reversed diet-induced disease in obese mice by delivering the drug directly into the liver.

The research team revealed that encapsulating drugs in a nanogel could be an effective way to treat similar diseases such as fatty liver disease, type 2 diabetes, and high cholesterol in the future.

Nanogel technology delivers a synthetic thyroid hormone drug called a thyroid mimetic. Thyroid hormones help keep metabolism in balance in the liver, but taking thyroid stimulants systemically reduces their effectiveness and comes with side effects.

Biomedical and chemical engineer S. says: Tai Theumanavan, from the University of Massachusetts Amherst in the US, said: "We realized that we needed to deliver this drug selectively to the liver, because if it moved to other places, it could cause complications."

Thiumannavan and his colleagues used mouse models to confirm that they could direct the nanogel carrier specifically to cells in the liver.

The researchers were able to package a thyroid mimetic, called Axiteromy, into anionic nanogels (ANGs) to administer to obese and control mice daily for five weeks via abdominal injection.

Meanwhile, obese mice were fed a diet high in fat, sugar and cholesterol for 24 weeks before treatment.

"The treated mice completely lost their gained weight, and we didn't see any unwanted side effects," says Theumannavan.

With the mice's diet maintained throughout the treatment period, not only did their weight return to normal, their cholesterol levels decreased, as did harmful levels of hepatitis.

“We found that we activate the reverse cholesterol transport pathway, which lowers cholesterol,” Thiumannavan says. “We believe that stimulating fat oxidation and increasing metabolic rate causes weight loss, but more work needs to be done to prove this point.”

The team explained that after the ANGs enter the liver cells, the oxytium is released when the environment in the liver cells breaks down the bonds in the nanogel. The drug then binds to a protein that helps regulate gene expression.

The ability of axitrome to reverse weight gain without causing widespread changes in thyroid hormone levels suggests the potential for thyroid stimulation to treat metabolic conditions such as obesity, which is a major public health problem.

The study was published in PNAS Nexus.

 

Nutrition : Consequences of not drinking enough water

Not drinking enough water per day leads to many problems that are especially reflected in the health of the elderly, so what is the amount of water that should be drunk per day?

And Dr. Yelena Solomatina, a Russian nutrition expert, points out that the widespread belief that a person needs two liters of water per day is incorrect. Because according to it, each person has his own privacy, that is, the amount of water that a person should drink varies from one person to another. It can be equivalent to 30 milliliters of water per kilogram of a person's weight.

The expert draws attention to the importance of drinking water evenly throughout the day, so that there are no cases in which a person does not drink water for a long time and then drinks a liter of water at once. Because this creates an unnecessary extra burden on the body, especially on the urinary system. Therefore, it is better to drink 2-3 sips every 20 minutes.

According to the expert, the consequences of lack of water in the body are too many: it negatively affects the brain; The condition and behavior of the person; Helps to form stones in the kidneys; Weakes the immune system; It causes problems in the digestive system, lungs, liver and other organs in the body.

She says, "The body begins to conserve water when it feels deficient, which leads to a rise in blood pressure and weight gain. The lack of water also negatively affects the appearance, as the condition of the skin, hair and nails worsens."

The expert points out that drinks such as tea, coffee and beer do not compensate for the lack of water in the body, but on the contrary lead to dehydration.